diffuse large b cell lymphoma | Who Classification of mature B-cell tumours, mature T, NK, Histiocytic, and Hodgkin's disease

Who Classification of mature B-cell tumours, mature T, NK, Histiocytic, and Hodgkin's disease


Mature B-cell lymphoid hemic


[An asterisk as a result of the category means that it was either modified or added to the WHO classification 2008]

Chronic lymphocytic leukemia/lymphocytic lymphoma

Lymphocytosis B monoclonal *

Prolymphocytaire leukemia B

Lymphoma of the splenic marginal zone

Hairy leukemia

Provisional entities: Leukemia/lymphoma splenic B Uncategorized

Small cell lymphoma B diffuse red pulp splenic

Hairy Leukemia variant

Lymphoplasmocytaire lymphoma

Waldenstrom of Macroglobulinemia

Monoclonal Gammapathie of indeterminate significance (MGUS) to IgM *

Heavy chain disease Mu

Gamma Heavy chain disease

Alpha Heavy chain disease

Monoclonal Gammapathie of indeterminate significance (MGUS) to IgG/A *

Multiple myeloma

Plasmacytoma Solitary Bone

Plasmacytoma Extra Bone

Monoclonal Ig Chain-deposition diseases *

Lymphoma of the marginal area (extra ganglion) of lymphoid tissue associated with mucous membranes (lymphoma MALT)

Lymphoma of the marginal ganglionic zone

Provisional entity: Lymphoma of the pediatric ganglionic marginal Zone
Follicular lymphoma

In situ follicular tumor (previously: in situ follicular lymphoma) *

duodenal Follicular type lymphoma *

Follicular lymphoma of pediatric type

Large cell B lymphoma with IRF4 rearrangement *

Centro Follicularis cutaneous lymphoma

Mantle cell lymphoma

In situ mantle cell tumor

Large-cell diffuse lymphoma B (DLBCL)

Without other specificity (NOS)

of type Centro Germ B *

Type B enabled *

B cell lymphoma with large cells rich in T cells and histiocytes

Primary central nervous System (DLBCL – CNS) Diffuse large cell lymphoma B

Large-cell diffuse lymphoma B primitive, leg type

Large B EBV + NOS Diffuse lymphoma *

Provisional entity: mucocutaneous ulcer EBV +

Diffuse large-cell lymphoma B associated with chronic inflammation

Granulomatosis Papulosis

Large-cell lymphoma B thymic Primitive

Intravascular Large cell lymphoma B

B ALK + Large cell lymphoma

Plasmoblastique lymphoma

Primitive lymphoma of serous

Provisional entity: Large cell lymphoma B HHV8 + NOS *

Burkitt's lymphoma

Provisional entity: Burkitt-like lymphoma with 11q anomaly *

High grade B lymphoma with MYC, BCL2 and/or BCL6 rearrangement *

High Grade lymphoma B *
Uncategorized B lymphoma with intermediate criteria between DLBCL and classical Hodgkin lymphoma

Hemic lymphoid cells with mature T-cell and NK


Prolymphocytaire leukemia T

Large granular lymphocyte leukemia

Provisional entity: lymphoproliferative Diseases of NK cells

Aggressive NK cell leukemia

Systemic T-lymphoma of the child EBV + *

Vacciniforme lymphoproliferative disease – like *

Leukemia/lymphoma T D el'adulte

T/NK extra ganglionic nasal lymphoma

T lymphoma with Enteropathy

Épithéliotrope intestinal monomorphic T-lymphoma *

Provisional entity: Lymphoproliferative disease T indolent of the gastrointestinal tract *

Hepatosplenic T lymphoma

Lymphoma T Type Panniculitis subcutaneous

Mycosis Fungoides

Sezary's Syndrome

CD30 + primitive cutaneous lymphoproliferative diseases

Lymphomatoid Papulosis

Anaplastic large cell lymphoma primitive skin

Gamma – Delta Primary skin cell lymphoma

Provisional entities: cytotoxic T cell lymphoma Épidermotrope primitive skin

CD8 + T Cell acral cutaneous lymphoma *

Primary cutaneous lymphoproliferative disease with small and medium CD4 + T cells *

Peripheral T Lymphoma Our

Immunoblastic T Angio lymphoma

Temporary entity: follicular lymphoma T *

Ganglionic peripheral T lymphoma with TFH phenotype *

Anaplastic lymphoma with large cells ALK +

ALK-* Large cell anaplastic lymphoma

Histiocytosis cell

Sarcoma with pancreatic cells

Undetermined dendritic cell tumor

Interdigitantes Dendritic cell tumor

Follicular sarcoma with dendritic cells

fibroblastic reticular Cell tumor

Juvenile disseminated Xanthogranuloma

Erdheim-Chester disease (to be distinguished from other members of the juvenile xanthomatosis family; often associated with a BRAF mutation) *

Tumors grouped in the same category, based on the functional properties of their normal counterpart (phagocytosis and/or modification and presentation of the GA), rather than their cellular origin? Most come from a common myeloid precursor, some cases are of mesenchymal origin (e.g. dendritic follicular cell sarcoma and fibroblastic reticular cell tumor).

Regardless of their myeloid or mesenchymal origin, some of these tumors are preceded or associated with follicular lymphoma, b LLC, B or T lymphoblastic lymphoma, or peripheral t lymphoma. These cases present the same IgVH, CRT, or chromosomal anomalies as associated lymphoid tumors (and a part also exhibits a mutation of BRAF) suggesting a process of trans differentiation.